Home•Blog•What is Facial Mesotherapy?

What is Facial Mesotherapy?

GeneralBurcu Yiğit Tekin3 min read•24 January 2026

Facial mesotherapy, intensive cellular regeneration and anti-aging is a treatment. A revitalizing solution composed of nutrients such as hyaluronic acid (HA), vitamins, amino acids, coenzymes, nucleic acids, minerals, and antioxidants is injected into the skin to rejuvenate it.

This active ingredient combination has the capacity to improve the physiological functions of fibroblasts, which play a key role in skin aging and are responsible for the production of collagen, elastin, and HA. However, this production naturally decreases with age.

The mesotherapy cocktail restores the components of the cellular matrix (extracellular matrix) and provides strong hydration, plumpness, and radiance to the dermis by supporting fibroblasts. It also smooths superficial wrinkles, reduces the appearance of spots, brightens dull skin, and creates a stimulating effect for the face.

The treatment is performed using a nano needle; this allows for nearly imperceptible micro-injections and provides high comfort for the patient. It can be applied for restorative purposes in mature skin, as well as offering excellent results preventively in younger patients.

Mesotherapy revitalizes and enhances the health of every skin type; it provides versatile benefits that are quite difficult to achieve without treatment, not just aesthetically.

Benefits of Facial Mesotherapy

Increases skin functionality; improves skin quality through fibroblast stimulation
Promotes an increase in collagen fibers, strengthens elastic fibers
Gives the skin radiance and brightness
Provides intense hydration
Creates softness in the skin
Balances skin tone and reduces pigmentation with an actinic rejuvenation effect
Increases skin firmness
Provides protection against external factors such as sunlight and tobacco by showing antioxidant effects
Offers high safety for sensitive areas such as around the eyes
Is independent of the season, can be applied at any time of the year
Is a minimal invasive, effective, and almost painless procedure

A Healthier Skin

Skin with a natural and positive expression evokes a sense of elegance and health without the need for makeup to conceal it. The revitalization provided by mesotherapy not only offers healthier skin but also brightens and soothes the skin tone; it improves the appearance of primary aesthetic concerns.

Main Areas Where Mesotherapy is Effective

Lower eyelid wrinkles
Wrinkles around the eyes
Perioral wrinkles
Fine expression lines
Under-eye bags
Skin texture deterioration
Dull skin appearance
Sagging and loss of elasticity
Skin spots

How Does Mesotherapy Work?

The effectiveness of mesotherapy is based on the combination of three key factors:

The injection itself, known as "mechanical stimulation," initiates the skin's repair and renewal mechanisms.
Active ingredients maximize the effectiveness of micro-injections by directly penetrating the treatment area.
"Micro doses" of the formula activate more skin receptors and optimize the absorption of active substances.

Facial Mesotherapy Before and After: How is the Treatment Applied?

Facial mesotherapy is a quick and simple procedure performed through micro-injections.

1. Before Treatment

The procedure does not require any special preparation from the patient; it is important to choose the right specialist and experienced team for the treatment. During the consultation, the doctor conducts a detailed assessment and cleanses the skin to prepare it for treatment.

2. Treatment Process

The procedure takes about 30 minutes. Although the puncture technique can be applied manually or with different devices, an advanced system that uses the finest needle on the market is preferred at Cinik Polyclinic. This system allows for precise determination of injection depth, puncture speed, and the amount of product to be applied to each patient. Despite the numerous injections performed with this method, marks are kept to a minimum and maximum precision is achieved. Micropunctures provide a safer, more comfortable experience, reduce the risk of bruising, and are nearly painless. The treatment provides biorevitalization, offers intense hydration, smooths fine wrinkles, and instantly gives the skin a glow. Facial mesotherapy is compatible with other applications such as hyaluronic acid, botulinum toxin, rejuvenating peels, microneedling, or intense pulsed light (IPL).

3. After Treatment: What to Consider After Facial Mesotherapy?

It is common to see slight redness (erythema) within the first 24 hours. This procedure is an outpatient treatment, and the patient can immediately return to their daily life. Although it can be performed at any time of the year, including summer months, it is recommended to avoid sunlight, UV rays, and temperatures below zero for at least 48 hours after the procedure. Facial mesotherapy is recommended to be done in two or three sessions per year, with one month between each session. The patient can repeat the treatment whenever they wish.

What Results Can I Expect After Mesotherapy?

You may notice the first effects immediately after the first session. This makes mesotherapy an ideal application before special occasions such as weddings, events, or holidays. However, at least 3 sessions are recommended to achieve the best and most lasting results.

If you want to take the powerful effects of mesotherapy a step further, you can combine the treatment with other facial applications like peels. If you want to improve your skin quality but find invasive procedures unsuitable, combining peeling with mesotherapy provides extremely effective results.

Are There Any Side Effects of Mesotherapy?

Mesotherapy is not recommended for pregnant or breastfeeding women or for individuals allergic to any of the active substances used in the procedure.

You can immediately continue your daily life after the mesotherapy session. However, it is advisable to avoid swimming pools or saunas, exposure to sunlight, and makeup for 24 hours after the treatment.

Facial Mesotherapy Prices

Facial mesotherapy price varies depending on the number of sessions, the products used, and the preferred clinic.

Frequently Asked Questions

What are the side effects of facial mesotherapy?

Possible side effects of facial mesotherapy may include redness and/or slight swelling at the application site (which is usually temporary and resolves within a few days), bruising (which often decreases within a few days), and a sensation of itching or burning (which resolves within minutes or hours).

Is anesthesia required during the treatment?

Generally, anesthesia is not required for facial mesotherapy, as the needles used are quite thin and the amount of substance injected is small. However, some individuals may experience slight discomfort during the procedure, especially in more sensitive areas of the face. In exceptional cases, a topical anesthetic cream may be applied before the procedure to reduce discomfort or pain.

PRP or Mesotherapy for the Face?

Mesotherapy and PRP are two effective and successful treatment methods in combating the signs of aging. Mesotherapy helps to increase skin elasticity, reduce wrinkles, and provide a youthful and vibrant appearance by deeply moisturizing the skin through high-nutrient injections.

PRP treatment supports collagen production, helping to tighten the skin and effectively reduce the appearance of fine lines and wrinkles. Those who undergo PRP and mesotherapy on their face are generally satisfied with the procedures.

How long does the effect of facial mesotherapy last??

The effect of facial mesotherapy typically lasts 4–6 months. This duration may vary depending on the individual's skin type, age, and lifestyle. Regularly scheduled sessions can help maintain the achieved effect for a longer period.

What should be considered after facial mesotherapy??